Dirdrah Aina C. Salvador
, FPOGS, FPSUOG De La Salle University Medical Center
Title: Single Loading Dose Versus Standard 24-Hour Magnesium Sulfate in Women with Severe Preeclampsia and Eclampsia: A Systematic Review and Metaanalysis
Biography
Biography: Dirdrah Aina C. Salvador
Abstract
Objectives: The primary goal of this study is to determine if a single loading dose of Magnesium sulfate (MgSO4) is comparable to standard 24-hour therapy in preventing seizures with severe preeclampsia and eclampsia
Study Design: Metaanalysis and Systematic review of six randomized controlled trials
Patients/ Subject Selection: Patients diagnosed with severe preeclampsia and eclampsia
Intervention: Giving of single loading dose only (study group) versus 24-hour MgSO4 therapy (control) in patients with severe preeclampsia and eclampsia
Outcome Measures: (1) Anti-convulsant effects (2) Maternal: loss of deep tendon reflex and oliguria, incidences of caesarean section, Hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, post-partum hemorrhage and intensive care unit admissions and (3) Neonatal complications: incidences of neonatal intensive care unit (NICU) admission, APGAR score at 5 minutes and death
Results: Occurrence of seizures was similar in both groups. The risk difference of -0.00 (95% Confidence interval (CI): -0.04 to 0.03; p=0.84) showed no significant difference and the combined studies were found to be homogenous with an I2 of 0.0.
Conclusion: A single loading dose of MgSO4 is comparable in preventing seizures of preeclamptic and eclamptic patients with similar maternal and neonatal complications except for a lesser occurrence of decreased patellar reflex in the study group (p=<000001).